1-(Oxetan-3-yl)piperazine → (S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(2-(4-(oxetan-3-yl)piperazin-1-yl)pyrimidin-4-yl)benzo[d]thiazol-6-yl)acetate

Participants

Reaction Steps

To (S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyrimidin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate (49.0 mg, 0.095 mmol) was added 1-(oxetan-3-yl)piperazine (27.0 mg, 0.190 mmol) in 1,4-dioxane (1 mL). The reaction mixture was stirred at room temperature for 6 h. Upon completion of the reaction, the reaction mixture was filtered through Celite (ethyl acetate eluent), concentrated, and used without further purification. LCMS-ESI+ calc'd for C32H37ClN5O4S (M+H+): 622.2; Found: 622.2 (M+H+).

Provenance & Evidence