HCID 5370806, compound → HCID 5369023, compound

Participants

Reaction Steps

506 g (1.8 mol) of iron (II) sulfate are initially introduced in 475 ml of water and 1000 ml of 25% NH4OH solution and heated to the boil. 79.3 g (228 mmol) of (E)-2-(4-bromophenyl)-3-(2-nitrophenyl)acrylic acid in a mixture of 150 ml of 10% NH4OH solution and 200 ml of THF are added dropwise over the course of 30 min, and the mixture is heated at the boil for a further 30 min. The reaction mixture is filtered hot through Celite, washed with warm 10% NH4OH solution and neutralised using acetic acid, and the resultant solid is filtered off with suction, washed with water and MeOH and dried. Yield of yellow, felt-like crystals: 52 g (72.3%).

Provenance & Evidence