Methylphenylacetylene → Diphenylacetylene

HRID 879940Notes

Reaction equation

HRID 879940 reaction equation
[C:1]1([C:7]#[C:8][CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C1(C)C=CC=CC=1>[C:1]1([C:7]#[C:8][C:9]2[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 69601Methylphenylacetylene

Product 1

HCID 10390DiphenylacetyleneYield 98.9%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
80 °C

Procedure

In a dry 25 mL Schlenk-tube, which has been flooded with argon, 1-phenyl-1-propine (1.00 mmol, 116.2 mg), [Mo(≡N)(OSiPh3)3(phen)].0.5 toluene (0.100 mmol, 116.2 mg), MnCl2 (0.100 mmol, 12.6 mg) and molecular sieve (1.00 g, 5 Å, powder) were suspended in 5 mL of toluene. The reaction solution was stirred for 3 h at 80° C. and was filtered after the cooling over a silica gel column. The filtrate was concentrated and the residue was purified by column chromatography (hexane). 88.1 mg of tolane (98%) were isolated as a white solid, the spectroscopic and analytical data of which were identical to those of a commercial sample. M.p.=59-61° C.

Workup

  1. filtrationwas filtered after the cooling over a silica gel column
  2. concentrationThe filtrate was concentrated
  3. customthe residue was purified by column chromatography (hexane)

Sources & evidence

ORD record
ord-f285f3183cc449469e67bbe547cde9d4
Source dataset
uspto-grants-2015_03
Patent number
US08993470B2

Reaction notes

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