Triethylamine → HCID 46865046, compound

Participants

Reaction Steps

1-Boc-amino-3-[diisopropylphosphonoformamido]propane (0.7 g, 4 mmol) was dissolved in 5 ml TFA. The reaction was stirred for 30 min. The excess of TFA was removed by evaporation in vacuo with toluene. To the residue in 15 ml DCM were added Et3N (5 eq, 2.8 ml, 20 mmol) and 4-phenoxybenzenesulfonyl chloride (1 g, 45 mmol). The reaction was stirred overnight at room temperature. The mixture was washed with 1N HCl; the organic layer was dried over Na2SO4 and the solvent was evaporated. The product was purified by silica gel chromatography [eluent: CHCl3/1-2% MeOH] to yield 1 g (50%) yellow oil.

Provenance & Evidence