Benzenesulfonyl chloride → HCID 136263766, compound

Participants

Reaction Steps

1.3 g of (2-chlorophenyl)-{5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridin-3-yl]-1,3,4-oxadiazol-2-yl}amine are dissolved in 15 ml of DMF at 60° C. When the solution has re-cooled to RT, 1.4 ml of triethylamine and 40 mg of dimethylaminopyridine are added. This solution is then cooled to 0° C., before 0.5 ml of benzenesulfonyl chloride is added dropwise. When the addition is complete, the batch is stirred at RT for a further 4 h. After undissolved constituents have been filtered off, the solution which remains is evaporated completely to dryness, and the residue is partitioned between ethyl acetate and water, with crystals precipitating out after a short time. The product is filtered off with suction and combined with the second crystal batch, giving 1.3 g of the title compound. HPLC-MS: Rt=2.567 min; [M+H+]: 532.1

Provenance & Evidence