Ethyl-3-hydroxy-dihydropyridone-4-carboxylic acid → Ethyl 3-hydroxy-2-oxo-1,2-dihydropyridine-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a solution of Intermediate 1A (20 g) in xylene (400 mL) was added 10% Pd/C (4 g). The mixture was heated at 130° C. for 24 h. The reaction was filtered through a pad of Celite®. Methanol was used for filtration and washing. The filtrate was concentrated and the residue was purified by ISCO flash chromatography (silica gel, 0-100% EtOAc/hexane) to give Intermediate 1B (15 g, 80% yield).

Provenance & Evidence