tert-Butyl azetidin-3-yl(methyl)carbamate → HCID 86730080, compound

HRID 880022Notes

Reaction equation

HRID 880022 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]2[CH2:17][CH2:16][CH:15]([NH2:18])C[CH2:13]2)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].N1CC(N(C)C(=O)OC(C)(C)C)C1>>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]2[CH2:13][CH:16]([CH2:15][NH2:18])[CH2:17]2)(=[O:10])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 23033645tert-Butyl azetidin-3-yl(methyl)carbamateHCID 28804119HCID 28804119, compound

Product 1

HCID 86730080HCID 86730080, compoundYield 87%

Procedure

Intermediate 5 (65 mg, 0.22 mmol, 87% yield) was prepared as a white powder following the procedure described for Intermediate 4 by replacing tert-butyl piperidin-4-yl-methylcarbamate with tert-butyl azetidin-3-yl-methylcarbamate. LC-MS (ESI) m/z 295 (M+H)+, RT=1.47 min (Method B).

Sources & evidence

ORD record
ord-dd63a2d4542647259557fb33856d39bf
Source dataset
uspto-grants-2015_03
Patent number
US08993557B2

Reaction notes

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