Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 3,4-Dichloro-N'-hydroxybenzene-1-carboximidamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3,4-Dichlorobenzonitrile | HCID 81051 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3,4-Dichloro-N'-hydroxybenzene-1-carboximidamide | HCID 11264185 | — |
반응 단계
A solution of 3,4-dichlorobenzonitrile (2.000 g, 11.63 mmol), hydroxylamine hydrochloride (1.649 mL, 12.79 mmol) and sodium hydroxide (4.15 mL, 12.4 mmol) in ethanol (40 mL) was stirred at rt for 1 h. Concentrated and refluxed in hexane for 30 min and concentrated in vacuo. The product Intermediate 1A was used directly for the next step. HPLC/MS (Method C) RT=1.24 min [M+H]+ 204.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08993557B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-7f9a9f93621a4f90b113d384f20d4f43 |
| 출처 메모 | uspto-grants-2015_03 |