Thionyl Chloride → HCID 86730090, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-isobutoxy-1-isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylate (Intermediate 8) (100 mg, 0.339 mmol) was added thionyl chloride (24.71 μL, 0.3390 mmol). The reaction mixture was stirred at 80° C. for 3 h. The solvent was evaporated under reduced pressure to give Example 52A which was used without further purification (90 mg, 0.315 mmol, 93% yield). LCMS RT=1.89 min [M+MeO+1]=282 {(MeOH/H2O/TFA) Phenom. Luna C18; 50×4.6 mm; 4 min Grad}.

Provenance & Evidence