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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 880076Generated: October 30, 2026

Water → HCID 136041737, compound

https://huagongshe.com/reaction/880076

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
Reactantm-ToluidineHCID 7934—
ReactantSodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetateHCID 136041844—
SolventEthanolHCID 702—
ProductHCID 136041737HCID 13604173759.7%

Reaction Steps

The product is prepared according to the procedure described in Example 19, using 261 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of Example 1 and using a mixture of 1 ml of water and 9 ml of ethanol in place of the methanol and 214 mg of 3-methylaniline in place of the 3-(tert-butyl)aniline. 196 mg of N-(3-methylphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08993565B2
Source datasetuspto-grants-2015_03
ORD IDord-4b9c08cbf2764c41bb6c5978afefd678
Source noteuspto-grants-2015_03