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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 880102Generated: October 30, 2026

4-Fluoro-3-(trifluoromethyl)aniline → HCID 136352195, compound

https://huagongshe.com/reaction/880102

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-(trifluoromethyl)anilineHCID 75377—
ReactantSodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetateHCID 136041844—
ProductHCID 136352195HCID 13635219555.7%

Reaction Steps

The product is prepared according to the procedure described in Example 5, using 260 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate and 358 mg of 4-fluoro-3-(trifluoromethyl)aniline in place of the 2,4-difluoroaniline. 222 mg of N-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the form of a white solid, the characteristics of which are the following:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08993565B2
Source datasetuspto-grants-2015_03
ORD IDord-2a6eeb483b8e43e18ce61fcf9fe191aa
Source noteuspto-grants-2015_03