4-Fluoroaniline → HCID 136041770, compound

HRID 880130Notes

Reaction equation

HRID 880130 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH3:9][CH:10]([CH3:30])[CH:11]([C:17]1[NH:18][C:19](=[O:29])[CH:20]=[C:21]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:22]=1)[C:12](OCC)=[O:13]>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:13])[CH:11]([C:17]2[NH:18][C:19](=[O:29])[CH:20]=[C:21]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[N:22]=2)[CH:10]([CH3:30])[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 136352206HCID 136352206, compound

Product 1

HCID 136041770HCID 136041770, compound

Procedure

The product is prepared according to the procedure described in example 70, using 0.023 ml of 4-fluoroaniline and 36 mg of ethyl 3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanoate in place of the ethyl [1-ethyl-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate. After purification by silica column chromatography, eluent: 940303 CH2Cl2/CH3CN/MeOH, 15 mg of N-(4-fluorophenyl)-3-methyl-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]butanamide are obtained in the form of a white solid, the characteristics of which are the following:

Workup

  1. customThe product is prepared
  2. customAfter purification by silica column chromatography, eluent

Sources & evidence

ORD record
ord-c98fc92534904b8a9d703c1d464ff56e
Source dataset
uspto-grants-2015_03
Patent number
US08993565B2

Reaction notes

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