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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 880202Generated: October 31, 2026

HCID 66882777, compound → HCID 136041838, compound

https://huagongshe.com/reaction/880202

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 66882777HCID 66882777—
ReactantSodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetateHCID 136041844—
SolventPyridineHCID 1049—
SolventDimethylformamideHCID 6228—
ProductHCID 136041838HCID 13604183844.2%

Reaction Steps

The product is prepared according to the procedure described in example 5, using 150 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 238 mg of (2,3-dihydro-1H-indol-3-ylmethyl)diethylamine and 140 mg of N-[3-(dimethylamino)propyl]-N-ethylcarbodiimide hydrochloride in a mixture of 0.1 ml of pyridine and 3 ml of N,N-dimethylformamide. 108 mg of 2-(2-{3-[(diethylamino)methyl]-2,3-dihydro-1H-indol-1-yl}-2-oxoethyl)-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a cream solid, the characteristics of which are the following:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08993565B2
Source datasetuspto-grants-2015_03
ORD IDord-c380a5850cb344d8974e6a7eb4797cbd
Source noteuspto-grants-2015_03