Hydrochloric Acid → N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide hydrochloride

Participants

Reaction Steps

Dissolve N-[(1R)-1-(4-{[(2S)-2-(4-fluorophenyl)morpholin-4-yl]methyl}phenyl)ethyl]methanesulfonamide (50 g, 127.39 mmol) in isopropyl alcohol (200 mL). Add HCl (4M in dioxanes; 63.70 mL, 254.78 mmol) drop-wise to the solution and stir at ambient temperature for 50 min. Remove the volatiles under reduced pressure; add H2O (200 mL); then evaporate the water. Add H2O (200 mL) and isopropyl alcohol (100 mL), and concentrate to a total volume of 80 mL. Filter the resulting thick slurry; wash solid with H2O; collect by filtration; and dry the filter cake under reduced pressure at 55° C. to provide the title compound as a white solid (40.6 g, 75%). MS (m/z): 393 (M-Cl).

Provenance & Evidence