反应详情

To a solution of methyl 3-(1-methyl-1H-pyrazol-5-yl)benzoate (200 mg, 0.93 mmol) in MeOH (3 mL) was added aqueous NaOH (1 mL, 0.4M). The mixture was stirred at room temperature for 2 h. The reaction solution was concentrated and the residue was dissolved in water and adjusted pH to 5˜6 with 2N of HCl. The solution was extracted with EtOAc (2×20 mL). The combined organic layers were dried and concentrated to give the target crude product which was used directly in the next step. LCMS (m/z): 203.1 (M+1).

1. concentrationThe reaction solution was concentrated
2. dissolutionthe residue was dissolved in water
3. extractionThe solution was extracted with EtOAc (2×20 mL)
4. customThe combined organic layers were dried
5. concentrationconcentrated
6. customto give the target crude product which