反应详情

To a solution of methyl 3-(pyridin-3-yl)benzoate (450 mg, 2.1 mmol) in MeOH (5 mL) was added aqueous of NaOH (1.5 mL, 0.4M). The mixture was stirred at room temperature for 2 h then reaction solution was concentrated and the resulting residue dissolved in water and adjusted pH to 5-6 with 2N HCl. Extracted was then performed using EtOAc with the organic layer dried and concentrated to give the target product which was used without further purification (600 mg, Yield 90%). LCMS (m/z): 200.1 (M+1).

1. customreaction solution
2. concentrationwas concentrated
3. dissolutionthe resulting residue dissolved in water
4. extractionExtracted
5. customdried
6. concentrationconcentrated
7. customto give the target product which
8. customwas used without further purification (600 mg, Yield 90%)