Sodium Hydroxide → 3-(Pyridin-3-yl)benzoic acid

HRID 880254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 880254
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([O:12]C)=[O:11])[CH:2]=1.[OH-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([OH:12])=[O:11])[CH:2]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 4133188Methyl 3-(3-pyridinyl)benzoate

Produkt 1

HCID 27955753-(Pyridin-3-yl)benzoic acidAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of methyl 3-(pyridin-3-yl)benzoate (450 mg, 2.1 mmol) in MeOH (5 mL) was added aqueous of NaOH (1.5 mL, 0.4M). The mixture was stirred at room temperature for 2 h then reaction solution was concentrated and the resulting residue dissolved in water and adjusted pH to 5-6 with 2N HCl. Extracted was then performed using EtOAc with the organic layer dried and concentrated to give the target product which was used without further purification (600 mg, Yield 90%). LCMS (m/z): 200.1 (M+1).

Aufarbeitung

  1. customreaction solution
  2. concentrationwas concentrated
  3. dissolutionthe resulting residue dissolved in water
  4. extractionExtracted
  5. customdried
  6. concentrationconcentrated
  7. customto give the target product which
  8. customwas used without further purification (600 mg, Yield 90%)

Quellen und Nachweise

ORD-Eintrag
ord-82871ca944874366afbedda866a76090
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993555B2

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