反应详情

To a solution of methyl 3-(pyridin-4-yl)benzoate (450 mg, 2.1 mmol) in MeOH (5 mL) was added an aqueous solution of NaOH (1.5 mL, 0.4M). The mixture was stirred at room temperature for 2 h. The reaction solution was then concentrated, the residue was next dissolved in water and adjusted pH to 5˜6 with the 2N HCl. After extraction with EtOAc, the organic layers were dried and concentrated to give the product desired (600 mg, Yield 90%). LCMS (m/z): 200.1 (M+1).

1. concentrationThe reaction solution was then concentrated
2. dissolutionthe residue was next dissolved in water
3. extractionAfter extraction with EtOAc
4. customthe organic layers were dried
5. concentrationconcentrated
6. customto give the product