HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 880330Generated: October 30, 2026
Dimethylformamide → 6-Chloropyrimidine-4-carbonyl chloride
https://huagongshe.com/reaction/880330
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 6-Chloro-4-pyrimidinecarboxylic acid | HCID 16637747 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Chloropyrimidine-4-carbonyl chloride | HCID 18422098 | 97.7% |
Reaction Steps
A drop of DMF was added to a stirred solution of 6-chloropyrimidine-4-carboxylic acid (5.5 g, 34.7 mmol) and (COCl)2 (12 mL) in DCM (100 mL). The mixture was stirred at 25° C. for 2 h. The solvent was evaporated under reduced pressure to give crude 6-chloropyrimidine-4-carbonyl chloride (6.0 g, yield: 97.7%). 1H NMR (400 MHz, DMSO-d6) δ 9.20 (s, 1H), 8.10 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08993555B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-64f5365940454dc09493ab7197d90127 |
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| Source note | uspto-grants-2015_03 |
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