Thiophosgene → 5-Bromo-6-isothiocyanatoquinoxaline

HRID 880348Notes

Reaction equation

HRID 880348 reaction equation
Br.[NH2:2][C:3]1[C:4]([Br:13])=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[N:6]2.[C:14](Cl)(Cl)=[S:15]>O>[Br:13][C:4]1[C:3]([N:2]=[C:14]=[S:15])=[CH:12][CH:11]=[C:10]2[C:5]=1[N:6]=[CH:7][CH:8]=[N:9]2

Participants

4

Reactant 2

HCID 10040ThiophosgeneHCID 183506656-Amino-5-bromoquinoxaline hydrobromide

Product 1

HCID 44602745-Bromo-6-isothiocyanatoquinoxaline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 6-amino-5-bromoquinoxaline hydrobromide (10 g) in distilled water (150 ml) is added thiophosgene (3 ml). The solution is stirred for two hours at room temperature and the resultant precipitate is collected by filtration, washed with water, and dried to afford 5-bromo-6-isothiocyanato-quinoxaline.

Workup

  1. filtrationthe resultant precipitate is collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-6b7e53c5c6e24da88f5e79a872020f41
Source dataset
uspto-grants-2015_03
Patent number
US08993571B2

Reaction notes

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