反应详情

A solution of ethyl 5-[2,4-bis(benzyloxy)-6-(4-nitrophenoxy)phenyl]isoxazole-3-carboxylate (1.8 g, 3.2 mmol) in 2 M ethylamine/THF solution (100 mL) in a stopped flask was heated at 100° C. for 5 hours. The solvent was removed and the residue was crystallized from a small volume of methanol to provide the title compound (1.45 g, 83% yield).

1. customThe solvent was removed
2. customthe residue was crystallized from a small volume of methanol