p-Fluoronitrobenzene → HCID 66759784, compound

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of 1-{2-hydroxy-4,6-bis[(2-methoxyethoxy)methoxy]phenyl}ethanone (2.1 g, 6 mmol), potassium carbonate (0.85 g, 6 mmol) and 1-fluoro-4-nitrobenzene (0.86 g, 6.1 mmol) in DMSO (5 mL) was heated at 80° C. overnight. After dilution with ethyl acetate, the suspension was washed with brine and dried. After removal of the solvent, the residue was chromatographed on silica gel eluting with hexane/ethyl acetate 6/4 to afford the title compound (1.6 g, 54% yield).

Provenance & Evidence