Hydrochloric Acid → Ethyl 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]isoxazole-3-carboxylate

Participants

Reaction Steps

To a stirred solution of ethyl 5-[2,4-bis(methoxymethoxy)-6-(4-nitrophenoxy)phenyl]isoxazole-3-carboxylate (25 g, 52 mmol) in ethanol (150 mL) was added 4 M HCl solution in dioxane at room temperature. The solution was set aside for 5 hours then the solvent was evaporated off and the residue taken up in diethyl ether, to provide the title compound (17.1 g, 83% yield).

Provenance & Evidence