HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 136013664, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Tetrahydro-4H-pyran-4-one | HCID 121599 | — |
| Reactant | HCID 136349812 | HCID 136349812 | — |
| Product | HCID 136013664 | HCID 136013664 | 53% |
Reaction Steps
Operating as in Example 24 Step 4, but employing N-(1-methylpiperidin-4-yl)-5-{2-[4-(amino)phenoxy]-4,6-dihydroxyphenyl}isoxazole-3-carboxamide instead of tert-butyl 4-{[(5-{2,4-bis[(2-methoxyethoxy)methoxy]-6-(4-aminophenoxy)phenyl}isoxazol-3-yl)carbonyl]amino}piperidine-1-carboxylate and tetrahydro-pyran-4-one instead formaldehyde, the title compound was obtained in 53% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993556B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-81a7b5d0916f4936a62657d58d6582ee |
| Source note | uspto-grants-2015_03 |