Hydrazine hydrate (1:1) → Ethyl 3-[2,4-bis(benzyloxy)-6-(4-nitrophenoxy)phenyl]-1H-pyrazole-5-carboxylate

Participants

Reaction Steps

A stirred solution of ethyl 4-[2,4-bis(benzyloxy)-6-(4-nitrophenoxy)phenyl]-2,4-dioxobutanoate (1 g, 1.75 mmol) and hydrazine hydrate (0.25 mL, 4.4 mmol) in ethanol (20 mL) was refluxed for 1 hour. The formed precipitate was filtered off and washed with ethanol and dried, to afford the title compound (0.69 g, 70% yield).

Provenance & Evidence