反应详情

4-[5-(Bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole (0.580 g, 1.28 mmol) was dissolved in dichloromethane (5 ml) and (2R,6S)-2,6-dimethylmorpholine (0.317 ml, 2.56 mmol) added. The reaction mixture was stirred at RT for 3 h then the solvent removed under a stream of nitrogen. The resultant yellow solid was dissolved in dichloromethane (5 ml) and washed with water (2×2.5 ml). The layers were separated (hydrophobic frit) and the organic evaporated in vacuo to give the title compound as a pale yellow solid (0.60 g).

1. customthe solvent removed under a stream of nitrogen
2. dissolutionThe resultant yellow solid was dissolved in dichloromethane (5 ml)
3. washwashed with water (2×2.5 ml)
4. customThe layers were separated (hydrophobic frit)
5. customthe organic evaporated in vacuo