HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 1-(6-Methyl-pyridin-2-yl)-4-(4-nitro-phenyl)-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| Reactant | 6-Chloro-2-picoline | HCID 87601 | — |
| Reactant | 2-Dicyclohexylphosphino-2-(N,N-Dimethylamino)Biphenyl | HCID 66545338 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(6-Methyl-pyridin-2-yl)-4-(4-nitro-phenyl)-piperazine | HCID 66914763 | — |
Reaction Steps
From 1-(4-nitro-phenyl)-piperazine and 2-chloro-6-methylpyridine, by heating in the presence of palladium (II) acetate, 2-dicyclohexylphospino-2-(N,N′-dimethyl amino)biphenyl and caesium carbonate in a mixture of toluene and THF to give 1-(6-methyl-pyridin-2-yl)-4-(4-nitro-phenyl)-piperazine then catalytic hydrogenation over Raney nickel in methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993574B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-7c448c091f054aef9391ce234f22e5a7 |
| Source note | uspto-grants-2015_03 |