反应详情

N-bromosuccinimide (590 mg, 3.30 mmol) was added to a solution of 1-methoxy-2-methyl-3-nitro-benzene (500 mg, 3.0 mmol) in carbon tetrachloride (5 mL) followed by a catalytic amount of dibenzoyl peroxide (25 mg). The reaction mixture was heated at reflux for 3 h then cooled to room temperature and poured into water. The organic phase was separated, washed with water (2×20 mL), dried over the anhydrous sodium sulfate and concentrated in vacuo to afford 2-(bromomethyl)-1-methoxy-3-nitro-benzene (640 mg, 86%) as a solid.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 3 h
3. customThe organic phase was separated
4. washwashed with water (2×20 mL)
5. dry with materialdried over the anhydrous sodium sulfate
6. concentrationconcentrated in vacuo