Potassium Nitrate → 5-Bromo-8-nitroisoquinoline

Participants

Reaction Steps

Potassium nitrate (1.17 g, 11.59 mmol) was added portion-wise to a solution of 5-bromo-isoquinoline (2.0 g, 9.66 mmol) in concentrated sulphuric acid (10 mL) and stirred at ambient temperature for 1 h. The reaction mixture was quenched with water and basified with aqueous ammonia. The aqueous layer was washed with water, brine, dried over anhydrous sodium sulphate and concentrated in vacuo to afford 5-bromo-8-nitro-isoquinoline (2.0 g, 82%) as a yellow solid.

Provenance & Evidence