Phosphorus oxide (P4O10) → HCID 66914929, compound

Participants

Reaction Conditions

Reaction Steps

Phosphorous pentoxide (4.14 g, 29.41 mmol) was added portion-wise to a solution of N-(2,2-dimethoxyethyl)-3-fluoro-4-nitro-benzamide (2.0 g, 7.35 mmol) in methane sulphonic acid (3 mL) at 0° C. over a period of 30 min. The mixture was heated to 145° C. for 5 h. The reaction mixture was allowed to cool to ambient temperature and quenched with crushed ice and then extracted with ethyl acetate. The combined organic layers were washed with water, brine, dried over anhydrous sodium sulfate and concentrated to afford the crude residue. Purification by flash chromatography with silica (60-120 mesh) using 15% ethyl acetate-petroleum ether as eluent to afforded 2-(3-fluoro-4-nitrophenyl)oxazole (500 mg, 33%) as a white solid.

Provenance & Evidence