HCID 178418361, compound → HCID 178423944, compound

HRID 880628Notes

Reaction equation

HRID 880628 reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH:15]([C:26]1[N:35]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:34](=[O:42])[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][C:32]=2[CH3:43])[N:27]=1)[NH:16][C:17]1[N:25]=[CH:24][N:23]=[C:22]2[C:18]=1[N:19]=[CH:20][NH:21]2)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[NH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH:15]([C:26]1[N:35]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:34](=[O:42])[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][C:32]=2[CH3:43])[N:27]=1)[NH:16][C:17]1[N:25]=[CH:24][N:23]=[C:22]2[C:18]=1[N:19]=[CH:20][NH:21]2

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178423943HCID 178423943, compound

Product 1

HCID 178423944HCID 178423944, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of compound 49 (28.5 mg) and palladium on carbon (10 mg, 10% Pd) in ethanol (2 mL) was shaken with hydrogen (40 psi) for 48 h. The mixture was filtered through CELITE® and the filtrate was concentrated to afford the product 54. ESI-MS m/z 455 (MH+). Compound 54 is shown below.

Workup

  1. filtrationThe mixture was filtered through CELITE®
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-949d397668c646da9cfa15bb231847aa
Source dataset
uspto-grants-2015_03
Patent number
US08993583B2

Reaction notes

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