Water → HCID 86649632, compound

HRID 880687Notes

Reaction equation

HRID 880687 reaction equation
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].[Br:9][C:10]1[CH:15]=[CH:14][C:13](N)=[C:12]([Cl:17])[CH:11]=1.O.C(#[N:21])C>>[Br:9][C:10]1[CH:15]=[CH:14][C:13]([CH:3]([C:2]([CH3:8])([CH3:7])[CH3:1])[C:4]([NH2:21])=[O:5])=[C:12]([Cl:17])[CH:11]=1

Participants

5

Reactant 4

HCID 962WaterHCID 6342AcetonitrileHCID 815143,3-Dimethylbutanoyl chlorideHCID 6101694-Bromo-2-chloroaniline

Product 1

HCID 86649632HCID 86649632, compoundYield 72%

Procedure

3,3-Dimethylbutanoyl chloride (717 mg, 0.74 mL, 5.32 mmol) was added to a solution of 4-Bromo-2-chloro-phenylamine (1.0 g, 4.84 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature overnight. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (1.04 g, 72% yield).

Workup

  1. customthe precipitate formed
  2. customcollected

Sources & evidence

ORD record
ord-e5712342629f48b7843d798807bab865
Source dataset
uspto-grants-2015_03
Patent number
US08993593B2

Reaction notes

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