Water → HCID 86649633, compound

HRID 880688Notes

Reaction equation

HRID 880688 reaction equation
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].[Br:9][C:10]1[CH:15]=[CH:14][C:13](N)=[C:12]([CH3:17])[CH:11]=1.O.C(#[N:21])C>>[Br:9][C:10]1[CH:15]=[CH:14][C:13]([CH:3]([C:2]([CH3:8])([CH3:7])[CH3:1])[C:4]([NH2:21])=[O:5])=[C:12]([CH3:17])[CH:11]=1

Participants

5

Reactant 4

HCID 962WaterHCID 6342AcetonitrileHCID 114234-Bromo-2-methylanilineHCID 815143,3-Dimethylbutanoyl chloride

Product 1

HCID 86649633HCID 86649633, compoundYield 56%

Procedure

3,3-Dimethylbutanoyl chloride (724 mg, 0.75 mL, 5.4 mmol) was added to a solution of 4-Bromo-2-methyl-phenylamine (1.0 g, 5.4 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature overnight. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (830 mg, 56% yield).

Workup

  1. customthe precipitate formed
  2. customcollected

Sources & evidence

ORD record
ord-cefb0a79901b4bd199c7f4950baaed74
Source dataset
uspto-grants-2015_03
Patent number
US08993593B2

Reaction notes

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