Water → HCID 86649634, compound

HRID 880689Notes

Reaction equation

HRID 880689 reaction equation
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].[Br:9][C:10]1[CH:15]=[CH:14][C:13](N)=[C:12]([C:17]([F:20])([F:19])[F:18])[CH:11]=1.O.C(#[N:24])C>>[Br:9][C:10]1[CH:15]=[CH:14][C:13]([CH:3]([C:2]([CH3:8])([CH3:7])[CH3:1])[C:4]([NH2:24])=[O:5])=[C:12]([C:17]([F:18])([F:19])[F:20])[CH:11]=1

Participants

5

Reactant 4

HCID 962WaterHCID 6342AcetonitrileHCID 679604-Bromo-2-(trifluoromethyl)anilineHCID 815143,3-Dimethylbutanoyl chloride

Product 1

HCID 86649634HCID 86649634, compoundYield 79%

Procedure

3,3-Dimethylbutanoyl chloride (617 mg, 0.64 mL, 4.6 mmol) was added to a solution of 4-Bromo-2-trifluoromethyl-phenylamine (1.0 g, 4.16 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature overnight. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (1.1 g, 79% yield).

Workup

  1. customthe precipitate formed
  2. customcollected

Sources & evidence

ORD record
ord-06cad7bf76d84c1c934be3a9b1fae3c4
Source dataset
uspto-grants-2015_03
Patent number
US08993593B2

Reaction notes

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