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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 880732Generated: October 30, 2026

4-(Trifluoromethyl)thiazole-2-carboxylic acid → N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-trifluoromethylthiazole-2-carboxamide

https://huagongshe.com/reaction/880732

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)thiazole-2-carboxylic acidHCID 18673010—
Reactant1-(2-Amino-3-chloro-4-methoxyphenyl)ethanoneHCID 29919988—
Reactant4-trifluoromethyl-4H-thiazole-2-carboxylic acid-(6-acetyl-3-methoxy-2-methyl-phenyl)-amideHCID 66730375—
ProductN-(6-acetyl-2-chloro-3-methoxyphenyl)-4-trifluoromethylthiazole-2-carboxamideHCID 5943482465%

Reaction Steps

N-(6-Acetyl-2-chloro-3-methoxyphenyl)-4-trifluoromethylthiazole-2-carboxamide 202d was synthesized from 4-(trifluoromethyl)-1,3-thiazole-2-carboxylic acid and 1-(2-amino-3-chloro-4-methoxyphenyl)-ethanone as a beige solid in 65% yield, following the procedure as described for compound 202b.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08993595B2
Source datasetuspto-grants-2015_03
ORD IDord-b1bf9a14224a4a20b7cae95ebfe1edcc
Source noteuspto-grants-2015_03