HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-trifluoromethylthiazole-2-carboxamide → 8-Chloro-2-(4-trifluoromethyl-thiazol-2-yl)-7-methoxy-quinolin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-trifluoromethylthiazole-2-carboxamide | HCID 59434824 | — |
| Reactant | HCID 178487696 | HCID 178487696 | — |
| Product | 8-Chloro-2-(4-trifluoromethyl-thiazol-2-yl)-7-methoxy-quinolin-4-ol | HCID 178487697 | 70% |
Reaction Steps
8-Chloro-7-methoxy-2-(4-trifluoromethyl-thiazol-2-yl)-quinolin-4-ol 203d was synthesized from compound 202d as a yellow powder in 70% yield, following the procedure as described for compound 203b. MS (ESI, EI+) m/z=361 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993595B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-a8a5711ba1494b30ae44f59ff6414dff |
| Source note | uspto-grants-2015_03 |