Boron tribromide → HCID 66819815, compound

Participants

Reaction Steps

To a solution of 68 mg (0.166 mmol) of 7-fluoro-3-(3-methoxy-phenyl)-4-(3-piperidin-1-yl-propoxy)-2H-isoquinolin-1-one hydrochloride (cmpd. 43) in anhydrous dichloromethane (1 mL), boron tribromide (1M in dichloromethane) (1 mL, 1 mmol) was added and the mixture was stirred overnight at room temperature under argon atmosphere. The solvent was concentrated under reduced pressure and the crude was purified by flash chromatography (eluant: starting with dichloromethane/methanol/acetone/7N ammonia in methanol: 93/3/3/1 to 88/6/5/1) to afford the free base, which was then converted into the hydrochloride salt according to common chemical procedures (58 mg of the title compound, 81%).

Provenance & Evidence