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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 880832Generated: October 31, 2026

Hydrochloric Acid → 2-(3-Amino-propylamino)-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide hydrochloride

https://huagongshe.com/reaction/880832

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant(3-{[(6-Oxo-5,6-dihydro-phenanthridin-2-ylcarbamoyl)-methyl]-amino}-propyl)-carbamic acid tert-butyl esterHCID 66819479—
SolventDichloromethaneHCID 6344—
Solvent1,4-DioxaneHCID 31275—
Product2-(3-Amino-propylamino)-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide hydrochlorideHCID 6681963797%

Reaction Steps

32 mg of (3-{[(6-oxo-5,6-dihydro-phenanthridin-2-ylcarbamoyl)-methyl]-amino}-propyl)-carbamic acid tert-butyl ester (0.075 mmol) were dissolved in dichloromethane (1 mL) and 4N hydrochloric acid in dioxane (1 mL) was added. The reaction mixture was stirred at room temperature overnight and then evaporated, affording 32 mg (97% yield) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08993594B2
Source datasetuspto-grants-2015_03
ORD IDord-f6fb3f75cccb4cc9acac3156bb2a46b4
Source noteuspto-grants-2015_03