6-Bromoisoquinolin-3-Amine → 3-Aminoisoquinoline-6-carboxylic acid

HRID 880939Notes

Reaction equation

HRID 880939 reaction equation
COC1C2C(=CC=C([C:13]([OH:15])=[O:14])C=2)C=CN=1.Br[C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[N:22][C:21]([NH2:27])=[CH:20]2>>[NH2:27][C:21]1[N:22]=[CH:23][C:24]2[C:19]([CH:20]=1)=[CH:18][C:17]([C:13]([OH:15])=[O:14])=[CH:26][CH:25]=2

Participants

3

Reactant 2

HCID 457898316-Bromoisoquinolin-3-AmineHCID 67491743HCID 67491743, compound

Product 1

HCID 674915953-Aminoisoquinoline-6-carboxylic acid

Procedure

The title compound was prepared by a method analogous to that described for Intermediate 12, Steps 2-3, using 6-bromoisoquinolin-3-amine. +ESI (M+H) 189.0; 1H NMR (400 MHz, DMSO-d6, δ): 13.15 (br. s., 1H), 8.94 (s, 1H), 8.20 (s, 1H), 7.91 (m, 1H), 7.62-7.59 (m, 1H), 6.78 (s, 1H), 6.14 (s, 2H).

Sources & evidence

ORD record
ord-1ca119e5caa44d0ba5510f60b29aec02
Source dataset
uspto-grants-2015_03
Patent number
US08993586B2

Reaction notes

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