Ethyl 1-(methylamino)isoquinoline-7-carboxylate → 1-(Methylamino)isoquinoline-7-carboxylic acid

HRID 880976Notes

Reaction equation

HRID 880976 reaction equation
COC1C=CC2C(=CC(C(O)=O)=CC=2)N=1.[CH3:16][NH:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([C:28]([O:30]CC)=[O:29])[CH:26]=2)[CH:21]=[CH:20][N:19]=1>>[CH3:16][NH:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([C:28]([OH:30])=[O:29])[CH:26]=2)[CH:21]=[CH:20][N:19]=1

Participants

3

Reactant 2

HCID 67491404Ethyl 1-(methylamino)isoquinoline-7-carboxylateHCID 674915922-Methoxy-7-quinolinecarboxylic acid

Product 1

HCID 674914721-(Methylamino)isoquinoline-7-carboxylic acid

Procedure

The title compound was prepared by a method analogous to that described in Step 3 of Intermediate 19, using ethyl 1-(methylamino)isoquinoline-7-carboxylate. +ESI (M+H) 203.1; 1H NMR (400 MHz, DMSO-d6, δ): 13.03 (br. s., 1H), 8.87 (s, 1H), 8.06 (dd, J=8.51, 1.47 Hz, 1H), 7.97 (d, J=5.67 Hz, 1H), 7.85 (d, J=4.50 Hz, 1H), 7.75 (d, J=8.41 Hz, 1H), 6.91 (d, J=5.87 Hz, 1H), 2.95 (d, J=4.50 Hz, 3H).

Sources & evidence

ORD record
ord-7aa1c7370e8643c2befe6e53e512da2a
Source dataset
uspto-grants-2015_03
Patent number
US08993586B2

Reaction notes

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