7-(trifluoromethyl)-1H-indazole-5-carboxylic acid → HCID 178524132, compound

HRID 880980Notes

Reaction equation

HRID 880980 reaction equation
FC(F)(F)C1C=C([C:12]([OH:14])=[O:13])C=C2C=1NN=C2.Br[C:18]1[CH:26]=[C:25]2[C:21]([C:22]([C:27]([F:30])([F:29])[F:28])=[N:23][NH:24]2)=[CH:20][CH:19]=1>>[F:28][C:27]([F:30])([F:29])[C:22]1[C:21]2[C:25](=[CH:26][C:18]([C:12]([OH:14])=[O:13])=[CH:19][CH:20]=2)[NH:24][N:23]=1

Participants

3

Reactant 2

HCID 674918107-(trifluoromethyl)-1H-indazole-5-carboxylic acidHCID 178506286HCID 178506286, compound

Product 1

HCID 178524132HCID 178524132, compound

Procedure

The title compound was prepared by a method analogous to that described in Steps 3-4 of Intermediate 21, using 6-bromo-3-(trifluoromethyl)-1H-indazole. −ESI (M−H) 229.1.

Sources & evidence

ORD record
ord-639b3122d2cd4ec5a6578538f6af3326
Source dataset
uspto-grants-2015_03
Patent number
US08993586B2

Reaction notes

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