1-(Methylamino)isoquinoline-7-carboxylic acid → Ethyl 1-(methylamino)isoquinoline-6-carboxylate

Participants

Reaction Steps

The title compound was prepared by a method analogous to that described in Step 1 of Intermediate 31, using ethyl 1-chloroisoquinoline-6-carboxylate. +ESI (M+H) 231.1; 1H NMR (400 MHz, CDCl3, δ): 8.39 (s, 1H), 8.06-8.14 (m, 2H), 8.00 (d, J=5.9 Hz, 1H), 7.02 (d, J=6.0 Hz, 1H), 4.44 (q, J=7.3 Hz, 2H), 3.25 (d, J=4.7 Hz, 3H), 1.43 (t, J=7.1 Hz, 3H).

Provenance & Evidence