HCID 178488147, compound → HCID 71750068, compound

HRID 881019Notes

Reaction equation

HRID 881019 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9]>CO>[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH3:10])[C:5]([CH2:11][N:14]2[C:13]([S:12]([CH2:11][C:5]3[C:6]([CH3:10])=[C:7]([O:8][CH3:9])[C:2]([CH3:1])=[CH:3][N:4]=3)=[O:24])=[N:21][C:20]3[CH:19]=[C:18]([O:22][CH3:23])[CH:17]=[CH:16][C:15]2=3)=[N:4][CH:3]=1

Participants

3

Reactant 1

HCID 178488147HCID 178488147, compound2×

Product 1

HCID 71750068HCID 71750068, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

For standards, 100 μg/mL concentration of omeprazole in methanol for a marker was prepared. A 0.1 μg/mL concentration of omeprazole was then prepared to set one-half the minimal detection limit. Then, a 1 μg/mL concentration of omeprazole impurity D in methanol was prepared. The chromatographic conditions were: Mobile Phase: 75% Na2PO4 pH 7.6, 25% acetonitrile; Flow Rate: 1.0 mL/min; Run Time: 30 min; Injection Volume: 20 μL; Detector: U.V., 280 nm; Column: Waters SymmetryShield RP8.

Workup

  1. custom30 min

Sources & evidence

ORD record
ord-dc3505b135244c7da7a2948da25f8859
Source dataset
uspto-grants-2015_03
Patent number
US08993599B2

Reaction notes

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