Potassium Carbonate → HCID 67114788, compound

Participants

Reaction Steps

A solution of intermediate 3 (8.0 g, 54.05 mmol) and K2CO3 (27.96 g, 202.6 mmol) in DMSO (60 mL) was heated at 110° C. under nitrogen for 0.5 h. To the mixture, 2-chloro-5-nitro pyridine (12.8 g, 80.75 mmol) was added and stirred at the same temperature for 2 h. Work-up (H2O/AcOEt) and purification afforded the title compound (3.03 g). 1H-NMR (δ ppm, CDCl3, 400 MHz): 9.24 (d, J 2.6, 1H), 8.51 (dd, J 2.6, 9.9, 1H), 8.10 (d, J 9.2, 1H), 5.72 (s, 1H), 2.90-2.75 (m, 1H), 1.99-1.90 (m, 1H), 1.06-0.93 (m, 4H), 0.82-0.64 (m, 4H).

Provenance & Evidence