Hydrochloric Acid → HCID 52913616, compound

Participants

Reaction Steps

Following the general procedure-1, N-[4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenyl]-2-(imidazo[1,2-a]pyridin-2-yl)acetamide (56 mg) was prepared from intermediate 29 (79 mg, 0.45 mmol) and intermediate 12 (90 mg, 0.38 mmol) as a brown solid and dissolved in THF. Saturated HCl in diethyl ether was added to this solution at 0° C. and stirred for 15 min. Solid that separated out was filtered and dried to give the title compound (54 mg) as a pale-brown solid. M. P. 92-97° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 10.82 (s, 1H), 8.92 (d, J 6.7, 1H), 8.32 (s, 1H), 7.97-7.92 (m, 2H), 7.75 (d, J 8.7, 2H), 7.53 (d, J 8.7, 2H), 7.52-7.47 (m, 1H), 5.79 (s, 1H), 3.80 (s, 2H), 1.87-1.71 (m, 2H), 0.93-0.79 (m, 4H), 0.69-0.58 (m, 4H). MS (m/z): 398.24 [M+H−HCl]+.

Provenance & Evidence