Hydrochloric Acid → HCID 52913846, compound

Participants

Reaction Steps

Following the general procedure-1, N-[4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)-3-fluorophenyl]-2-(quinolin-6-yl)acetamide (95 mg) was prepared from intermediate 13 (200 mg, 0.78 mmol) and intermediate 30 (232 mg, 1.2 mmol) as an yellow solid and dissolved in THF. Saturated HCl in diethyl ether was added to this solution at 0° C. and stirred for 15 min. Solid that separated out was filtered and dried to give the title compound (50 mg) as an yellow solid. M. P.: 106.8-108.2° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 10.99 (s, 1H), 9.24 (d, J 4.5, 1H), 9.09 (d, J 8.0, 1H), 8.32-8.25 (m, 2H), 8.12 (d, J 8.6, 1H), 8.05-8.01 (m, 1H), 7.83 (d, J 11.3, 1H), 7.50-7.41 (m, 2H), 5.73 (s, 1H), 4.07 (s, 2H), 1.84-1.76 (m, 1H), 1.52-1.42 (m, 1H), 0.82-0.74 (m, 4H), 0.62-0.52 (m, 4H). MS (m/z): 427.10 [M+H]+.

Provenance & Evidence