Hydrochloric Acid → HCID 52913848, compound

Participants

Reaction Steps

Following the general procedure-1, N-[6-(3,5-dicyclopropyl-1H-pyrazol-1-yl)pyridin-3-yl]quinoline-6-carboxamide (71 mg) was prepared from intermediate 26 (103 mg, 0.59 mmol) and intermediate 14 (120 mg, 0.49 mmol) as an orange solid and dissolved in THF. Saturated HCl in diethyl ether was added to this solution at 0° C. and stirred for 15 min. Solid that separated out was filtered and dried to give the title compound (62 mg) as an yellow solid. M. P. 232-238° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 11.09 (s, 1H), 9.25 (d, J 4.0, 1H), 9.02 (d, J 7.3, 1H), 8.93 (d, J 8.4, 2H), 8.53 (d, J 9.0, 1H), 8.43-8.36 (m, 2H), 8.02-7.95 (m, 1H), 7.78 (d, J 8.8, 1H), 5.83 (s, 1H), 2.74-2.65 (m, 1H), 1.93-1.84 (m, 1H), 1.00-0.80 (m, 4H), 0.74-0.58 (m, 4H). MS (m/z): 393.94 [M−H−2HCl]−.

Provenance & Evidence