Hydrochloric Acid → HCID 52913958, compound

Participants

Reaction Steps

Following the general procedure-1, N-[6-(3,5-dicyclopropyl-1H-pyrazol-1-yl)pyridin-3-yl]-2-(quinolin-6-yl)acetamide (138 mg) was prepared from intermediate 30 (112 mg, 0.59 mmol) and intermediate 14 (120 mg, 0.49 mmol) as a pale yellow solid and dissolved in THF. Saturated HCl in diethyl ether was added to this solution at 0° C. and stirred for 15 min. Solid that separated out was filtered and dried to give the title compound (34 mg) as an off-white solid. M. P. 62-67° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 10.86 (s, 1H), 9.21 (d, J 4.4, 1H), 9.04 (d, J 8.1, 1H), 8.69 (s, 1H), 8.30-8.22 (m, 2H), 8.18 (d, J 8.1, 1H), 8.09 (d, J 8.4, 1H), 8.00-7.97 (m, 1H), 7.68 (d, J 8.8, 1H), 5.80 (s, 1H), 4.05 (s, 2H), 2.69-2.55 (m, 1H), 1.89-1.75 (m, 1H), 0.97-0.78 (m, 4H), 0.70-0.50 (m, 4H). MS (m/z): 410.26 [M+H−2HCl]+.

Provenance & Evidence