Hydrochloric Acid → HCID 52913960, compound

Participants

Reaction Steps

Following general procedure-1, N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}quinoline-6-carboxamide (35 mg) was prepared from intermediate 26 (85 mg, 0.49 mmol) and intermediate 15 (120 mg, 0.45 mmol) as a brown solid (35 mg) and dissolved THF. Saturated HCl in diethyl ether was added to the solution at 0° C. and stirred for 15 min. Solid that separated out was filtered and dried to give the title compound (30 mg) as an yellow solid. M. P. 188-192° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 10.86 (s, 1H), 9.15 (d, J 4, 1H), 8.80-8.78 (m, 2H), 8.39 (d, J 8.8, 1H), 8.26 (d, J 8.8, 1H), 8.04 (d, J 8.8, 2H), 7.83-7.80 (m, 1H), 7.67 (d, J 8.8, 2H), 6.62 (s, 1H), 1.89-1.84 (m, 1H), 1.00-0.96 (m, 2H), 0.84-0.80 (m, 2H). MS (m/z): 457.16 [M−H]−.

Provenance & Evidence