Hydrochloric Acid → HCID 52913842, compound

Participants

Reaction Steps

Following the general procedure-1, N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-(quinolin-6-yl)propanamide (74 mg) was prepared from intermediate 15 (150 mg, 0.56 mmol) and intermediate 38 (180 mg, 0.89 mmol) as a brown solid and dissolved in THF. Saturated HCl in diethyl ether was added to this solution at 0° C. and stirred for 15 min. Solid that separated out was filtered and dried to give the title compound (45 mg) as a brown solid. M. P.: 168-170° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 10.61 (s, 1H), 9.11 (d, J 3.7, 1H), 8.87 (d, J 8, 1H), 8.18 (d, J 9, 2H), 8.07 (dd, J 1.6, 8.8, 1H), 7.85 (dd, J 4.9, 8.3, 1H), 7.79 (d, J 8.9, 2H), 7.55 (d, J 8.9, 2H), 6.59 (s, 1H), 4.20 (q, J 6.8, 1H), 1.80-1.70 (m, 1H), 1.57 (d, J 6.8, 3H), 1.00-0.90 (m, 2H), 0.80-0.70 (m, 2H). MS (m/z): 451.11 [M+H−HCl]−.

Provenance & Evidence