Hydrochloric Acid → HCID 52914065, compound

Participants

Reaction Steps

Following the general procedure-1, N-{6-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridin-3-yl}-2-(quinolin-6-yl)acetamide (67 mg) was prepared from intermediate 30 (133 mg, 0.71 mmol) and intermediate 17 (120 mg, 0.45 mmol) as a pale yellow solid and dissolved in THF. Saturated HCl in diethyl ether was added to this solution at 0° C. and stirred for 15 min. Solid that separated out was filtered and dried to give the title compound (63 mg) as a white solid. M. P. 225-230° C. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 10.96 (s, 1H), 9.15 (d, J 4.4, 1H), 8.90 (d, J 8.0, 1H), 8.80 (d, J 2.3, 1H), 8.30 (dd, J 2.4, 8.8, 1H), 8.21 (d, J 8.7, 1H), 8.18 (s, 1H), 8.03 (d, J 8.3, 1H), 7.90 (dd, J 5, 8.2, 1H), 7.75 (d, J 8.8, 1H), 6.61 (s, 1H), 4.06 (s, 2H), 2.51-2.40 (m, 1H), 1.01-0.90 (m, 2H), 0.81-0.70 (m, 2H). MS (m/z): 436.02 [M−H−2HCl]−.

Provenance & Evidence